General Information

  • ID:  hor002587
  • Uniprot ID:  A8Y1S8
  • Protein name:  NLP-12
  • Gene name:  nlp-12
  • Organism:  Caenorhabditis briggsae
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0031739 cholecystokinin receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0060756 foraging behavior
  • GO CC:  GO:0043005 neuron projection; GO:0043025 neuronal cell body

Sequence Information

  • Sequence:  TQSPTFDRQD
  • Length:  10
  • Propeptide:  MLRNSCVLVLLILVFVDVFATQSPTFDRQDRDYRPLQFGKRDGYRPLQFGKRDYRPLQFGKRSGGGSVVLEPIWEWQ
  • Signal peptide:  MLRNSCVLVLLILVFVDVFA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A8Y1S8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002587_AF2.pdbhor002587_ESM.pdb

Physical Information

Mass: 135493 Formula: C49H75N15O20
Absent amino acids: ACEGHIKLMNVWY Common amino acids: DQT
pI: 4.11 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 1
Hydrophobicity: -195 Boman Index: -4900
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 14500 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  18760316
  • Title:  Comparative Peptidomics of Caenorhabditis Elegans Versus C. Briggsae by LC-MALDI-TOF MS